April 23, 201115 yr All the things mentioned will help, but I find that if you ride only sporadically and spend the rest of your life in an office blisters are inevitable. Last summer I did a 534 mile off road race solo after almost a decade off the bike. Had great gloves etc, but still blistered badly (gloves soaked in blood by the end - nabbed 5th overall though!). Followed that up with 2 months of riding off road nearly every day and by the end of it my hands toughened up nicely. Sadly I've been sat in an office since.
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