I am picking up a brand new, 2025 301rr next week. It will be my first. I seem to be unaware of what the specifics are related to a fuel pump issue, other than there seems to be one.

Is there anything I should ask from the dealer either before I buy or when I pick up about this? What should I look for in terms of this problem and what has been the resolution?

From a dealer? Maybe ask if he stocks a replacement fuel pump and the cost, if he says no then it should give you a hint how often they need replacing.

There was a problem with a manufacturing process with one of the materials used in fuel pumps, the issue wasn’t exclusive to 4rt’s but appeared on many Honda products. Hopefully the affected parts have been removed form production by now.

In 2024 there was a recall issued by Honda in regard to faulty pump impellers. You should not be too worried about recalls, those are issues that have been identified and in theory resolved. The biggest ownership problem with the fuel pump system is that the high pressure filter canister is not a replacement item and only offered as an entire fuel pump assembly. Don't drop the bike in a lake or you will be looking at an expensive repair.